In 1972, Campus Health Services announced that they would no longer be a 24/7 in-patient health care facility. Students saw a need for a way for students to be transported to off-campus doctors’ offices and hospitals. Founding members Adam Bernstein and Jon-Marc Weston received approval to start using a station wagon for transportation. In the fall of 1973, Harpur's Ferry put a 1963 Cadillac ambulance into service. After servicing the University for 23 years with basic care, Harpur’s Ferry became an Advanced Life Support agency in 1996.
In 2001, the agency purchased a Ford F-450 Wheeled Coach Ambulance and dedicated it to Christine McHugh, a member who died in an auto accident. Since then, Harpur’s Ferry has operated two ambulances full time. A year later the agency bought a Chevrolet Blazer as a first response/chief’s vehicle. In 2005, Harpur’s Ferry won the first ever National Collegiate EMS Foundation "ALS Skills Competition" at the NCEMSF Conference in Philadelphia, PA. The agency was also awarded the New York State EMS Agency of The Year at the 2005 Vital Signs Conference in Rochester, NY. 2005 was also the first year Harpur's Ferry stayed in service for the entire calendar year. The agency also purchased a John Deere Gator to be used for sporting events and in the Nature Preserve on campus.